The pharmaceutical industry is the largest part of the healthcare sector that deals with devices and medications that combat some of the world’s deadliest diseases for humans and animals. This industry directly affects all the world, which is a great social responsibility. Research has shown that for pharmaceutical companies to stay in the business and make a profit, the decision may be made to acquire another company or merge with another organization to provide have a successful business. The new company may have to create a new culture. This study aims to determine how the transition after a merger or acquisition can impact the company’s retention rates. Based on a review of literature on leadership and training implementation styles and training curriculum content, surveys were distributed, and interviews were conducted after training was conducted. Analysis of the responses demonstrated that many factors influence retention rates at pharmaceutical companies, however the key to retain employees is to provide a training program that will align the businesses that will create a positive company culture from management. On this basis, it is recommended that after a merger or acquisition that an evaluation is conducted of the training system and that a culture training curriculum is designed to adhere to FDA regulations. Further research is needed to identify other factors that could strengthen the effectiveness of the training plan to maintain or increase retention rates after the completion of a merger or acquisition. This additional research will also provide insight on how effective the training provided to employees was on the culture and productivity of the company.